We have recently developed a web app, juProt (https://juprot.info/) to compare protein-ligand interactions between two complexes. The manuscript has been accepted in the journal, insilico Pharmacology.

We also developed jSeqTB, an ML integrated Linux GUI application for the analysis of NGS data of Mycobacterium tuberculosis. The work was presented as a poster at the International Conference for AI on Genomics and Drug Design (ICAGDD) 2026 in Bharathiar University, Coimbatore and won Best Poster award. See Poster

Data Science | Development

• juProt: A Web Application for Comparative Analysis of Protein-Ligand Interactomes

  • Manuscript accepted in insilico Pharmacology

• jSeqTB: A Biophysically-Aware Al Pipeline for Real-Time Mycobacterium tuberculosis Drug Resistance Profiling

  • Poster presented; won Best Poster award at the International Conference for AI on Genomics and Drug Design (ICAGDD) 2026 in Bharathiar University, Coimbatore.

• Machine Learning-Based Prediction of Diabetic Retinopathy and Nephropathy Progression: Evaluating Hornerin and SFN as Novel Biomarkers

  • Manuscript in Communication with the International Journal of Diabetes in Developing Countries

Aromatase | Breast Cancer | Computational Biology

• Virulence Factors of the Microbiome: A Functional Toolkit for Cancer Progression

  • Manuscript accepted in the journal, Molecular and Clinical Oncology

• Evaluation of Ginsenosides and their Derivatives from Panax ginseng as Aromatase Inhibitors for Breast Cancer Treatment - An in silico study

  • Manuscript accepted in the journal, BioMed Research International

• Mallur, Dhrithi Jayasimha, B. Lavanya, Sheshadri S. Temkar, V. Arun, and Benedict C. Paul. "Exploring okra-derived compounds as prospective aromatase inhibitors: a computational study for enhanced breast cancer therapy." Journal of Biomolecular Structure and Dynamics (2024): 1-9.

• Temkar, Sheshadri S., Amruta Sridhara, Dhrithi Jayasimha Mallur, Deepak Ishwara Shivaprakash, Divya Iyengar, Nritam Das, and Benedict Paul C. 2024. “Potential Aromatase Inhibitors from Centella Asiatica with Non-Synonymous SNPS - A Computational Approach.” Current Computer-Aided Drug Design 20 (4): 341–58. doi: 10.2174/1573409919666230525151933. PMID: 37231718

• Paul, C. Benedict, and C. Sudandiradoss. "Functional and structural characterization of deleterious nsSNPs of Cyp19a1 based on binding affinity and stability-A computational approach." Gene Reports 5 (2016): 34-39.

• BENEDICT, PAUL C., and C. SUDANDIRADOSS. AROMATASE INHIBITORS-TYPES AND ADVANTAGES International Journal of Pharmacy and Pharmaceutical Sciences, 8 (8) (2016), 1–7.

Enterococcus faecalis | Dental Pathogens | PCR

• Virulence Gene Prevalence in Enterococcus faecalis from Dental Infections in South India

  • Manuscript has been accepted in the journal, Indian Journal of Microbiology Research

• Dhanushiya R, Abinaya S, Siva V, Paul CB. Investigating the presence and virulence potential of Enterococcus faecalis, with a focus on the hyaluronidase factor, in environmental samples: Insights from a pilot study. Sri Ramachandra J Health Sci. doi: 10.25259/SRJHS_55_2023

• Lokitha R. , Nandakumar Namitha, Harish K. , Arulmozhi P. , Jayakumar Aarthi, Anbarasi K. and Benedict Paul C.*, Antimicrobial Therapeutic Strategies for Enterococcus faecalis In Dental Infections - Past, Present and Future, Anti-Infective Agents 2023; 21(3) : e200123212930

• M. Prasanth, Meera Raju, S. Divakar, S. Abirami, H. Hajarah, K. Uma Harini, S. Senthilnathan, Benedict Paul C. (2016). Detection of gelE and factors affecting gelatinase activity of enterococcus faecalis isolates. Asian Jr. of Microbiol. Biotech. Env. Sc., 18(1), 257–261.

• Manohar, Prasanth, Gowtham Kumar G, Hajarah Hussain, and Benedict Paul C. (2016). “Distribution of virulence factors among vancomycin resistant enterococcus faecalis from dental isolates.” Asian Journal of Pharmaceutical and Clinical Research 9 (3): 103–5.

Collaboration

• A Review on Prognostic Biomarker and Phytocompound-Mediated Modulation of Signaling Pathways in Colorectal Cancer

  • Manuscript accepted in the journal, Personalized Medicine

• Goutham PAJ, Kalaiselvam R, Ganesh A, Benedict Paul C. Antibacterial Efficacy of Irrigants with Varying Osmolarity on E. faecalis Biofilm: An In Vitro Study. J Contemp Dent Pract. 2022 Oct 1;23(10):998-1003. doi: 10.5005/jp-journals-10024-3417. PMID: 37073912.

• Appapalam, Selvakumar Thanganadar, Benedict Paul, Sumathy Arockiasamy, and Rajasekar Panchamoorthy. "Phytofabricated silver nanoparticles: Discovery of antibacterial targets against diabetic foot ulcer derived resistant bacterial isolates." Materials Science and Engineering: C (2020): 111256. (Impact Factor 5.88)

• Hemalatha, C. R., P. A. Abhinand, Maithreyi Iyer, Benedict C. Paul, Anupma Jyoti Kindo, Thyagarajan Ravinder, and P. Dhanapalan. "Phytochemical derivatives targeting fliJ flagellar protein from Escherichia coli." Bioinformation 14, no. 9 (2018): 465-470.

• Rosaline H, Kandaswamy Deivanayagam J, Paul B. Depth of penetration and biovolume of enterococcus faecalis and fusobacterium nucleatum biofilm into dentinal tubules using confocal microscope and co-aggregation assay. ejpmr, 2018,5(5), 270-274.

• Markandeyan, D., Kannaiyan, S., Suresh, S., Nimmakayala, R., Ilamurugan, R., Santhalingam, K., & Benedict Paul C. (2016). Virtual screening of phytochemicals for methotrexate like dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide (aicar) transformylase inhibitory property using molegro virtual docker. International Journal of Pharmacy and Pharmaceutical Sciences, 8(5), 83–87.

• Markandeyan, D., K. Santhalingam, S. Kannaiyan, S. Suresh, and Benedict Paul C. “VIRTUAL SCREENING OF PHYTOCHEMICALS OF MORINDA CITRIFOLIA AS ANTI-INFLAMMATORY AND ANTI-ALZHEIMER AGENTS USING MOLEGRO VIRTUAL DOCKER ON p38-α MITOGEN ACTIVATED PROTEIN KINASE ENZYME”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 6, Nov. 2015, pp. 141-5

Masters Dissertation

• Padmesh, P., Reji, J. V., Benedict Paul, C., Mukunthakumar, S., Praveen, G., & Seeni, S. (2009). Analysis of genetic variability in two diploid Musa cultivars using RAPD. Biologia Plantarum, 53(4), 711–714. doi:10.1007/s10535-009-0128-6.